This paper details a “metadisciplinary” applied ethics course jointly taught and pioneered by a biologist, psychologist, and ethicist on the subject of Assisted Reproduction. Contrasted with a transdisciplinary approach (whose content involves themes or issues that span traditional disciplinary lines) and a multidisciplinary approach (which involves experts from several disciplines working side by side), a metadisciplinary approach involves both of these former characteristics while incorporating a continuous, critical appreciation for the strengths and weaknesses of the contrasting methods and scopes of (...) each discipline’s methods of inquiry. This paper details the kinds of subjects that lend themselves to metadisciplinary approaches (e.g. applied ethics subjects which are real-world, complex, and studied by various disciplines), staffing guidelines for a smoothly functioning core team, how to plan and prepare the day-to-day of such a course to prevent a diffuse lesson structure, assignment and evaluation guidelines, and an appraisal of the value of such a class. The authors argue that while fundamental research may be conducted along traditional disciplinary lines, solutions to the complex problems of contemporary society require people who are equipped with problem-solving skills whose relevance spans disciplinary boundaries. (shrink)

Public values failure occurs when the market and the public sector fail to provide goods and services required to achieve the core values of society such as equity (Bozeman 2007). That public policy for emerging health technologies should address intrinsic societal values such as equity is not a novel concept. However, the ways that the public values discourse of stakeholders is structured is less clear and rarely studied through the lens of public interests. This is especially true in the health (...) sciences discourse. Using the public value mapping (PVM) model I present a case study of the intrinsic value of equity in nanomedicine for cancer and the imperatives for translational research, an instrumental value to achieve equity. After reviewing and coding nearly 700 value statements from several hundred public documents, I find that that the discourse on values varies between documents that address basic research and documents that address the application of the knowledge produced in basic research, with some especially notable disconnections. This paper demonstrates the importance of further refinement of methods for testing the PVM framework if the societal goal is to improve consistency of the public value discussion by those involved in developing and applying new technologies. The paper also demonstrates the value of a PVM approach for complex science policy analysis, especially for emerging technologies like nanomedicine. (shrink)

Is Leo Strauss truly an intellectual forebear of neoconservatism and a powerful force in shaping Bush administration foreign policy? _The Truth about Leo Strauss_ puts this question to rest, revealing for the first time how the popular media came to perpetuate an oversimplified view of a complex and wide-ranging philosopher. In doing so, it corrects our perception of Strauss, providing the best general introduction available to the political thought of this misunderstood figure. Catherine and Michael Zuckert—both former students of (...) Strauss—guide readers here to a nuanced understanding of how Strauss’s political thought fits into his broader philosophy. Challenging the ideas that Strauss was an inflexible conservative who followed in the footsteps of Nietzsche, Heidegger, and Carl Schmitt, the Zuckerts contend that Strauss’s signature idea was the need for a return to the ancients. Through their work, they conclude that Strauss was a sober defender of liberal democracy, aware of both its strengths and its weaknesses. Balanced and accessible, _The Truth about Leo Strauss_ is a must-read for anyone who wants to more fully comprehend this enigmatic philosopher and his much-disputed legacy. “_The Truth about Leo Strauss_ is the most balanced and insightful book yet written about Strauss’s thought, students, and political influence. It dispels myths promulgated by both friends and foes and persuasively traces the conflicting paths that American thinkers indebted to Strauss have taken.”—William Galston, Brookings Institution. (shrink)

Formalised knowledge systems, including universities and research institutes, are important for contemporary societies. They are, however, also arguably failing humanity when their impact is measured against the level of progress being made in stimulating the societal changes needed to address challenges like climate change. In this research we used a novel futures-oriented and participatory approach that asked what future envisioned knowledge systems might need to look like and how we might get there. Findings suggest that envisioned future systems will need (...) to be much more collaborative, open, diverse, egalitarian, and able to work with values and systemic issues. They will also need to go beyond producing knowledge about our world to generating wisdom about how to act within it. To get to envisioned systems we will need to rapidly scale methodological innovations, connect innovators, and creatively accelerate learning about working with intractable challenges. We will also need to create new funding schemes, a global knowledge commons, and challenge deeply held assumptions. To genuinely be a creative force in supporting longevity of human and non-human life on our planet, the shift in knowledge systems will probably need to be at the scale of the enlightenment and speed of the scientific and technological revolution accompanying the second World War. This will require bold and strategic action from governments, scientists, civic society and sustained transformational intent. (shrink)

Mammalian sperm undergo discharge of a single, anterior secretory granule following their attachment to the zona pellucida surrounding the oocyte. This secretory discharge is known for historical reasons as the acrosome reaction. It fulfils a number of purposes and without it, sperm are unable to penetrate the zona pellucida and fuse with the oocyte. In this review, we focus on the role of the acrosome reaction in the development of fusion competence in sperm. Any naturally occurring membrane fusion has two (...) major sequential steps: a docking or adhesion step, in which two membranes adhere, and a fusion step, in which their lipid bilayers are destabilized and merged and a cellular compartment is either created or destroyed. Recent evidence suggests that there is an important role for oocyte integrins and sperm‐bound disintegrins in mammalian sperm/oocyte adhesion and fusion. The fusion mechanism employed by sperm remains poorly understood, however, and circumstantial evidence suggests it is more complex than the interaction between a single protein species and its target. Sperm/oocyte fusion is probably the most accessible eukaryotic model for intercellular fusion currently available, partly because it is temporally separated from gene expression. Elucidation of the mechanism of sperm/oocyte fusion may throw light on the mechanism of other intercellular fusions such as myoblast fusion, and the evolutionary relationship of intercellular membrane fusion to intracellular membrane fusion. (shrink)

This book has been written in the hopes of equipping teachers-in-training—that is, teacher candidates—with the skills needed for action research: a process that leads to focused, effective, and responsive strategies that help students succeed.

Leo Strauss and his alleged political influence regarding the Iraq War have in recent years been the subject of significant media attention, including stories in the _Wall Street Journal _and _New York Times._ _Time_ magazine even called him “one of the most influential men in American politics.” With _The Truth about Leo Strauss_, Michael and Catherine Zuckert challenged the many claims and speculations about this notoriously complex thinker. Now, with _Leo Strauss and the Problem of Political Philosophy_, they turn (...) their attention to a searching and more comprehensive interpretation of Strauss’s thought as a whole, using the many manifestations of the “problem of political philosophy” as their touchstone. For Strauss, political philosophy presented a “problem” to which there have been a variety of solutions proposed over the course of Western history. Strauss’s work, they show, revolved around recovering—and restoring—political philosophy to its original Socratic form. Since positivism and historicism represented two intellectual currents that undermined the possibility of a Socratic political philosophy, the first part of the book is devoted to Strauss’s critique of these two positions. Then, the authors explore Strauss’s interpretation of the history of philosophy and both ancient and modern canonical political philosophers, including Plato, Aristotle, Machiavelli, and Locke. Strauss’s often-unconventional readings of these philosophers, they argue, pointed to solutions to the problem of political philosophy. Finally, the authors examine Strauss’s thought in the context of the twentieth century, when his chief interlocutors were Schmitt, Husserl, Heidegger, and Nietzsche. The most penetrating and capacious treatment of the political philosophy of this complex and often misunderstood thinker, from his early years to his last works, _Leo Strauss and the Problem of Political Philosophy_ reveals Strauss’s writings as an attempt to show that the distinctive characteristics of ancient and modern thought derive from different modes of solving the problem of political philosophy and reveal why he considered the ancient solution both philosophically and politically superior. (shrink)

Philosophie de la culture grecque est un ouvrage qui rassemble une cinquantaine de textes de différentes origines. Cet ouvrage s’inscrit dans le prolongement des travaux d’E. Moutsopoulos, parmi lesquels La musique dans l’œuvre de Platon, La philosophie de la musique dans la dramaturgie antique. Formation et structure ou encore Les structures de l’imaginaire dans la philosophie de Proclus. L’unité de l’ouvrage se dégage au terme d’un parcours où se découvre progressivement sa logique interne. Les grands moments, c’est-à-dire aussi les grandes (...) figures, de la philosophie grecque depuis ses origines jusqu’au XXe siècle y sont présentés. L’idée directrice est de montrer le rayonnement de la pensée grecque dans l’histoire de l’Occident et d’en exposer les temps forts. L’influence décisive de la Grèce dans le passé, sous le nom d’humanisme, peut et doit être prolongée, selon notre auteur, dans l’Europe d’aujourd’hui. Composé de sept parties, l’ouvrage est centré sur ces deux grandes figures que sont Platon et Aristote, autour et à partir desquelles la philosophie s’est développée. L’enjeu de l’ouvrage est dans son titre même, puisqu’il s’agit de la possibilité d’une philosophie de la culture grecque. (shrink)

Human beings are epistemically interdependent. Much of what we know and much of what we need to know we glean from others. Being a gregarious bunch, we are prone to venturing opinions whether they are warranted or not. This makes information transfer a tricky business. What we want from others is not just information, but reliable information. When we seek information, we are in the position of enquirers not examiners. We ask someone whether p because we do not ourselves already (...) know whether p. So we cannot check our informant’s bona fides by seeing whether she is speaking the truth about p. We need grounds for trust. In What’s the Point of Knowledge? Michael Hannon maintains that this is the predicament that underlies the concept of knowledge. The we here is comprehensive. Evidently, every language has a word for knowledge. This, Hannon suggests, indicates that the concept of knowledge satisfies a universal human need. A goal, if not the goal, of epistemology is to identify that need and ascertain how it is satisfied. Following Craig, Hannon argues that the point of knowledge is to enable us to identify good – that is, suitably reliable – informants. Let us call this the information transfer view. (shrink)

Alliant l’étude de sources historiques et les méthodes anthropologiques d’analyse de terrains et d’entretiens, Lucy Green étudie le rapport à la musique des femmes sous l’angle de l’éducation féminine, entendue comme éducation à la féminité, renforcée ou menacée par la pratique musicale. Dans la première partie de l’ouvrage, l’auteur se penche sur la signification culturelle et sociale des pratiques musicales féminines à travers l’histoire. S’interrogeant sur la tendance de ces dernières à tr...

Kim Sterelny and Paul Griffiths (Sterelny 1992, Sterelny and Griffiths 1999) have argued that sociobiology is unworkable because it requires that human behaviors can be adaptations; however, behaviors produced by a functionalist psychology do not meet Lewontin's quasi-independence criterion and therefore cannot be adaptations. Consequently, an evolutionary psychology which regards psychological mechanisms as adaptations should replace sociobiology. I address two interpretations of their argument. I argue that the strong interpretation fails because functionalist psychology need not prevent behaviors from evolving independently, (...) and it relies on too strong an interpretation of the quasi-independence criterion. The weaker interpretation does not undermine sociobiology, and evolutionary psychology would be vulnerable to the same criticism. Finally, I offer reasons to think that both mental mechanisms and behaviors can be adaptations. (shrink)

Relevance Theory is a cognitively oriented theory of pragmatics, i.e., a theory of language use. It builds on the seminal work of H.P. Grice1 to develop a pragmatic theory which is at once philosophically sensitive and empirically plausible (in both psychological and evolutionary terms). This entry reviews the central commitments and chief contributions of Relevance Theory, including its Gricean commitment to the centrality of intention-reading and inference in communication; the cognitively grounded notion of relevance which provides the mechanism for explaining (...) pragmatic interpretation as an intention-driven, inferential process; and several key applications of the theory (lexical pragmatics, metaphor and irony, procedural meaning). Relevance Theory is an important contribution to our understanding of the pragmatics of communication. (shrink)

CRISPR‐Cas technology accelerates development of fast, accurate, and portable diagnostic tools, typified by recent applications in COVID‐19 diagnosis. Parasitic helminths cause devastating diseases afflicting 1.5 billion people globally, representing a significant public health and economic burden, especially in developing countries. Currently available diagnostic tests for worm infection are neither sufficiently sensitive nor field‐friendly for use in low‐endemic or resource‐poor settings, leading to underestimation of true prevalence rates. Mass drug administration programs are unsustainable long‐term, and diagnostic tools – required to be (...) rapid, specific, sensitive, cost‐effective, and user‐friendly without specialized equipment and expertise – are urgently needed for rapid mapping of helminthic diseases and monitoring control programs. We describe the key features of the CRISPR‐Cas12/13 system and emphasise its potential for the development of effective tools for the diagnosis of parasitic and other neglected tropical diseases (NTDs), a key recommendation of the NTDs 2021–2030 roadmap released by the World Health Organization. (shrink)

One of the central critiques of the bourgeois conception of public holds that, in its implicit claim to universality, it fails to account for the material particularities of social groups and for the variety of possible rationalities. Some theorists have aimed to solve this problem by describing particular publics and particular rationalities based on racial, ethnic, gender, or political identities. While particularist public models represent difference in protest of the totalizing and counterfactual valence of a bourgeois conceptualization of public, they (...) fail to acknowledge that glossing difference is fundamental to the function of and the authorizing power of public, as it is marshalled by speakers. By analogizing Perelman and Olbrechts-Tyteca's universal audience with public, this paper (a) introduces the public metonym, a rhetorically productive counterfactual totality that glosses the material particularities of social groups, (b) critiques the particularist approach to the paradox of public, (c) introduces the resistance metonym as a rhetorically-minded alternative, and (d) clarifies distinctions among projects that claim to address a common object called pUblic. (shrink)

Structures of multisubunit RNA polymerases strongly differ from the many known structures of single subunit DNA and RNA polymerases. However, in functional complexes of these diverse enzymes, nucleic acids take a similar course through the active center. This finding allows superposition of diverse polymerases and reveals features that are functionally equivalent. The entering DNA duplex is bent by almost 90° with respect to the exiting template–product duplex. At the point of bending, a dramatic twist between subsequent DNA template bases aligns (...) the “coding“ base with the binding site for the incoming nucleoside triphosphate (NTP). The NTP enters through an opening that is found in all polymerases, and, in most cases, binds between an α‐helix and two catalytic metal ions. Subsequent phosphodiester bond formation adds a new base pair to the exiting template–product duplex, which is always bound from the minor groove side. All polymerases may undergo “induced fit” upon nucleic acid binding, but the underlying conformational changes differ. BioEssays 24:724–729, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

ABSTRACTTask-irrelevant emotional expressions are known to capture attention, with the extent of “emotional capture” varying with psychopathic traits in antisocial samples. We investigated whether this variation extends throughout the continuum of psychopathic traits in a community sample. Participants searched for a target face among facial distractors. As predicted, angry and fearful faces interfered with search, indicated by slower reaction times relative to neutral faces. When fear appeared as either target or distractor, diminished emotional capture was seen with increasing affective-interpersonal psychopathic (...) traits. However, moderation analyses revealed that this was only when lifestyle-antisocial psychopathic traits were low, consistent with evidence suggesting that these two facets of psychopathic traits display opposing relationships with emotional reactivity. Anxiety did not show the predicted relationships with emotional capture effects. Findings show... (shrink)

La question de la cohérence de la théorie rawlsienne de la justice et de son tournant politique a été depuis longtemps une source de débats et de malentendus. Pour certains interprètes, l’abandon par le second Rawls d’un fondement kantien des principes de justice au profit d’un libéralisme purement politique serait un prix trop élevé à payer pour obtenir un large consensus sur des principes de justice dans des sociétés démocratiques traversées par des conflits de valeurs insurmontables. « La vérité dérangeante (...) ( inconvenient truth ) que Rawls découvre est qu’il est impossible, écrit Robert Taylor (2011), de parvenir à un consensus par recoupement sur une conception kantienne de la personne ou plus largement sur la justice comme équité », mais qu’en même temps, sans un tel fondement, la force morale de la théorie de la justice serait diluée. Dans cet article, je voudrais répondre à ces critiques et montrer que, bien loin de conduire au relativisme, l’exigence d’autonomie doctrinale et d’indépendance des principes de justice à l’égard de toute conception substantielle du Bien exprimée par Rawls ( Libéralisme politique, p. 133) exprime le sens qu’a pour lui l’idéal démocratique : le respect pour l’autonomie morale des personnes et le rejet de « la pratique séculaire de l’intolérance comme condition nécessaire à l’ordre et à la stabilité de la société » ( Libéralisme politique, p. 14). Mais un tel idéal n’est-il pas irréaliste? Faire ainsi confiance à l’autonomie des citoyens, à leur capacité à distinguer entre leurs doctrines morales personnelles et des principes publics de justice ( Libéralisme politique, p. 7) ne risque-t‑il pas d’affaiblir les démocraties au lieu de garantir leur stabilité, comme l’espère Rawls ( Libéralisme politique, p. 4)? Cette ambition d’autonomie doctrinale est-elle une force ou une faiblesse de la théorie rawlsienne? (shrink)

Dans son dernier ouvrage, Des Femmes en littérature, Martine Reid mène une enquête riche et passionnante, très bien théorisée et solidement documentée, sur la place des femmes écrivains dans l’histoire littéraire française et « dans la mémoire collective depuis des siècles » (p. 5). Si les exemples retenus couvrent surtout les auteures (le plus souvent leurs productions romanesques) du XVIIIe siècle au début du xxe siècle, la réflexion met en lumière non seulement la conception « résolument m...

In lieu of an abstract, here is a brief excerpt of the content:Buddhist-Christian Studies 21.1 (2001) 130-132 [Access article in PDF] Book Review Faith Among Faiths: Christian Theology and Non-Christian Religions Faith Among Faiths: Christian Theology and Non-Christian Religions. By James L. Fredericks. Mahwah, New Jersey: Paulist Press, 1999. 188 pp. "The time has come to recognize that the debate between exclusivists, inclusivists, and pluralists has reached an impasse."This is the starting point and refrain of Faith Among Faiths. While James (...) Fredericks discerns questions and problems relating to all three models for Christian theological attitudes toward religious pluralism, it is predominantly the pluralist approach that he takes to task. In the first part of this slender volume, he offers a summary of some of the main proponents of the pluralist theology of religion. The ideas of John Hick and Paul Knitter are given separate treatment in a chapter on each, with two "other pluralist voices"--Wilfred Cantwell Smith and Stanley Samartha--also discussed at some length. In order to assess the adequacy of these theologies, Fredericks tests them against two important criteria: [End Page 130] responsibility to the Christian tradition as it has articulated itself, and ability to respond creatively to the challenges and opportunities posed by religious plurality today. Regarding the first criterion, most pluralist theologies are shown to fall short of recognizing the full humanity and divinity of Jesus Christ and hence in some measure to break from continuity with Christian faith. In a useful reminder, Fredericks rightly points to the similarities between pluralist Christologies and the nineteenth-century liberal Protestant views of Jesus, and then joins Pannenberg in criticizing this theocentric understanding of Jesus as unbiblical. At the same time, Fredericks attempts to head off the possible charge that he moves toward biblicism or traditionalism by stating that "the traditional teaching about the divinity and the humanity of Jesus is traditional because of the spiritual and ethical implications that flow from it" (p. 124). The evident importance of this assertion makes it regrettable that he does not elaborate or explain it further.Most of Fredericks's criticism of the pluralist approach is based on his second criterion, i.e., the need to take seriously the manifest similarities and differences between religions and, in turn, promote a genuinely fruitful dialogue. From this perspective, the problem with pluralism would be its "domestication of differences" between the religions. When a pluralist such as John Hick proposes that all religions are reflections of the same ultimate reality and that all religious paths lead to the same ultimate goal, Fredericks thus sees a tendency to undermine the importance of religious differences and of the self-understanding of other religions. While this may indeed be a danger lurking in an abstract conception of the pluralist position, I do not believe that it is a necessary or inherent consequence of it. The basic distinction that most pluralists make between the "ultimate reality" itself, which is absolutely transcendent, and the historical manifestations of this "ultimate reality" does not necessarily reduce the different religions to equally adequate or inadequate manifestations of that ultimate reality. On the plane of phenomenal reality, there is still room for a hierarchy of truths and, inter alia, the possibility of growing in one's understanding of truth through dialogue with other religions. There is, moreover, ample evidence of this in the fact that some of the aforementioned pluralists have also written very detailed works on other religions (e.g., Cantwell Smith on Islam) or on particular aspects of other religions (Hick on conceptions of death and the afterlife in world religions). As we have seen in the case with the Buddhist notion of upaya,he recognition of the relative nature of all conditioned reality does not necessarily lead to a relativism in which all differences become insignificant.After criticizing the different pluralist approaches to the theology of religions, Fredericks proposes a shift to comparative theology. He seems to see comparative theology not so much as a new paradigm or orientation within the theology of religions but as a radical alternative to the whole enterprise of the theology of religions... (shrink)

John Wilkins and Malte Ebach respond to the dismissal of classification as something we need not concern ourselves with because it is, as Ernest Rutherford suggested, mere ‘‘stamp collecting.’’ They contend that classification is neither derivative of explanation or of hypothesis-making but is necessarily prior and prerequisite to it. Classification comes first and causal explanations are dependent upon it. As such it is an important (but neglected) area of philosophical study. Wilkins and Ebach reject Norwood Russell Hanson’s thesis that classification (...) relies on observation that is theory-laden and deny the need for aetiological assumptions and historical reconstruction to justify its arrangement. What they offer instead is a significant (albeit controversial) contribution to the philosophical literature on classification, a pre-theoretic natural classification based on the observation of patterns in data of ready-made phenomena. Their notion of ready-made phenomena rests on a conception of tacit knowledge or know-how. This is evident in their distinction between strong Theory-dependence and na ̈ıve theory-dependence. Their small t-theory-dependence permits patterns of observation that facilitate know-how but does not rely on a domain-specific explanatory theory of their aetiology. Wilkins and Ebach suggest classification differs from theory building in that it is passive (whereas theory building is active). Classification is possible just because it does not require the sieve of theory to capture classes that are ‘‘handed to you by your cognitive dispositions and the data that you observe’’ (p. 18). Finding regularities sans-theory is just something we do and can do without any prior theory about the underlying causes or origins of the resultant regularities. Luke Howard’s classification of clouds serves as an exemplar of a passive, theory-free classification system and the periodic table and the DSM help to illustrate this type of non-aetiological patterning. A recurrent theme is the nature of naturalness. For Wilkins and Ebach, the conception of naturalness is not one that is based on the generation or discovery of natural kind categories popular in both the traditional metaphysics of Mill and Wittgenstein as well as updated notions within philosophy of biology such as Boyd’s Homeostatic Property Cluster kinds. Instead, Wilkins and Ebach define the naturalness of classification as the falling into hierarchical patterns, aligning the search for natural arrangement with the aim of systematics, and as something that is grounded in a cognitive task or activity. However, they leave the question of realism v. antirealism open. ‘‘In natural classification...we must have real relations no matter how we might interpret ‘real’’’ (p. 70). There is tension with regard to their ontological commitments as they vacillate between constructive, operationalist, and realist approaches. Wilkins and Ebach initially define real as that which is causal and important (pp. 70–71), and later as that which ‘‘depends in no way upon a mind or observer’’ (p. 122). This makes their claim that there was ‘‘no real theory involved [in the pre-Darwinian classifications of Jussieu and Adanson]’’ (p. 64) difficult to interpret. Cont’d……. (shrink)

L'exercice de la violence est largement, massivement, le fait des humains mâles. Les femmes, ou humains femelles, en sont souvent les principales victimes. Mais tel n'est pas l'objet de cet ouvrage. Lorsque, exceptionnellement, des femmes ont recours à des actes de violence, sont elles-mêmes auteurs de tels actes, elles transgressent les normes, les frontières imposées à leur seule catégorie de sexe. Ce sont ces cas de dissidence, de subversion, de transgression qui intéressent Hacker...

Cette plaquette, de facture élégante, est due à un chercheur spécialisé dans l'histoire de la population de Metz sous la Révolution et l'Empire. Louise Louise de Poutet fait partie de ces femmes qui ont divorcé pendant la Révolution, contracté un nouveau mariage, puis réépousé leur premier mari. L'attention du chercheur a été retenue par une pièce d'archive : un mémoire du second époux. Loin d'apparaître comme un partenaire fictif, c'est un amoureux payé de retour qui proteste contre l..

Interoception can be broadly defined as the sense of signals originating within the body. As such, interoception is critical for our sense of embodiment, motivation, and well-being. And yet, despite its importance, interoception remains poorly understood within modern science. This paper reviews interdisciplinary perspectives on interoception, with the goal of presenting a unified perspective from diverse fields such as neuroscience, clinical practice, and contemplative studies. It is hoped that this integrative effort will advance our understanding of how interoception determines well-being, (...) and identify the central challenges to such understanding. To this end, we introduce an expanded taxonomy of interoceptive processes, arguing that many of these processes can be understood through an emerging predictive coding model for mind–body integration. The model, which describes the tension between expected and felt body sensation, parallels contemplative theories, and implicates interoception in a variety of affective and psychosomatic disorders. We conclude that maladaptive construal of bodily sensations may lie at the heart of many contemporary maladies, and that contemplative practices may attenuate these interpretative biases, restoring a person’s sense of presence and agency in the world. (shrink)

Psychiatry is rapidly adopting digital phenotyping and artificial intelligence/machine learning tools to study mental illness based on tracking participants’ locations, online activity, phone and text message usage, heart rate, sleep, physical activity, and more. Existing ethical frameworks for return of individual research results (IRRs) are inadequate to guide researchers for when, if, and how to return this unprecedented number of potentially sensitive results about each participant’s real-world behavior. To address this gap, we convened an interdisciplinary expert working group, supported by (...) a National Institute of Mental Health grant. Building on established guidelines and the emerging norm of returning results in participant-centered research, we present a novel framework specific to the ethical, legal, and social implications of returning IRRs in digital phenotyping research. Our framework offers researchers, clinicians, and Institutional Review Boards (IRBs) urgently needed guidance, and the principles developed here in the context of psychiatry will be readily adaptable to other therapeutic areas. (shrink)

Née en 1553, morte en 1611, cette forte personnalité compte dans l'histoire de la Provence au temps des guerres de religion : elle anime la Ligue aixoise. L'historiographie la salue encore aux XVIIe et XIXe siècle, puis elle s'enfonce dans l'oubli. L'intérêt pour les femmes de pouvoir au XVIe siècle, la mise à l'honneur d'héroïnes à contre-emploi des rôles féminins traditionnels la replacent en lumière. Cette biographie à caractère scientifique, écrite par une ingénieure de recherches ..

Copenhagen interpretation of quantum mechanics deals with these problems is reviewed. A new interpretation of the formalism of quantum mechanics, the transactional interpretation, is presented. The basic element of this interpretation is the transaction describing a quantum event as an exchange of advanced and retarded waves, as implied by the work of Wheeler and Feynman, Dirac, and others. The transactional interpretation is explicitly nonlocal and thereby consistent with recent tests of the Bell inequality, yet is relativistically invariant and fully causal. (...) A detailed comparison of the transactional and Copenhagen interpretations is made in the context of well-known quantum-mechanical Gedankenexperimenre and "paradoxes." The transactional interpretation permits quantum-mechanical wave functions to be interpreted as real waves physically present in space rather than as "mathematical representations of knowledge" as in the Copenhagen interpretation. The transactional interpretation is shown to provide insight into the complex character of the quantum-mechanical state vector and the mechanism associated with its "collapse." It also leads in a natural way to justification of the Heisenberg uncertainty principle and the Born probability law (P = ii iij*), basic elements of the Copenhagen interpretation. (shrink)

Firms are spending billions annually in the name of corporate social responsibility (CSR). Whilst markets are increasingly willing to reward good and responsible firms, they lack the instruments to measure corporate social performance (CSP). To convince investors and other stakeholders, firms invest heavily in building a reputation for good corporate behaviour. This article argues that reputations for CSP are often unrepresentative of true CSP and investigates how differences in 'perceived' and 'actual' – as measured by the Fortune and KLD databases, (...) respectively – can partly be explained by firm characteristics. Amongst other things, it finds that overrated firms are more likely to be relatively big, profitable, operating in non-polluting but competitive industries and with no history of wrong doings to their primary stakeholders. They will also typically spend a lot of effort satisfying the claims of their secondary stakeholders. Above all, the results emphasise the need for researchers to recognise that the databases measure different phenomenon and are not interchangeable. (shrink)

Cet ouvrage de R. B. Onians, un classique dans le monde anglo-saxon, est enfin disponible au public français. Son titre ambitieux exprime le projet de l'auteur: comprendre comment notre pensée occidentale s'est construite en remontant à sa source originelle et essentielle, à celui qui fut considéré comme l'éducateur des Grecs: Homère. Le nerf de cette compréhension est l'analyse du vocabulaire, principalement homérique donc, qui situe cet ouvrage, comme l'indique à juste titre B. Cassin, dans sa présentation de l'édition française, «entre (...) dictionnaire étymologique et vocabulaire spécialisé». Cette compréhension s'appuie sur l'examen des croyances relatives à l'âme et au corps, à la vie, à la mort, aux dieux et à leurs rôles dans la sphère humaine, au destin et au temps chez les peuples grec et romain. Ce volume est divisé en trois parties: L'esprit et le corps; L'âme immortelle et le corps; Le destin et le temps. (shrink)

This book offers a rich collection of voices from diverse settings and illustrates ways in which lectio divina as a contemplative practice can transform teaching and learning. Drawing on holistic education and embodied learning, lectio divina empowers teachers and roots students in their own meaning making.

In qualitative interviews with a diverse group of experts, the vast majority believed unregulated researchers should seek out independent oversight. Reasons included the need for objectivity, protecting app users from research risks, and consistency in standards for the ethical conduct of research. Concerns included burdening minimal risk research and limitations in current systems of oversight. Literature and analysis supports the use of IRBs even when not required by regulations, and the need for evidence-based improvements in IRB processes.

The current study examines patterns of attachment/self-protective strategies and rates of unresolved loss/trauma in children and adolescents presenting to a multidisciplinary gender service. Fifty-seven children and adolescents (8.42–15.92 years; 24 birth-assigned males and 33 birth-assigned females) presenting with gender dysphoria participated in structured attachment interviews coded using dynamic-maturational model (DMM) discourse analysis. The children with gender dysphoria were compared to age- and sex-matched children from the community (non-clinical group) and a group of school-age children with mixed psychiatric disorders (mixed psychiatric (...) group). Information about adverse childhood experiences (ACEs), mental health diagnoses, and global level of functioning was also collected. In contrast to children in the non-clinical group, who were classified primarily into the normative attachment patterns (A1-2, B1-5, and C1-2) and who had low rates of unresolved loss/trauma, children with gender dysphoria were mostly classified into the high-risk attachment patterns (A3-4, A5-6, C3-4, C5-6, and A/C) (χ2= 52.66;p< 0.001) and had a high rate of unresolved loss/trauma (χ2= 18.64;p< 0.001). Comorbid psychiatric diagnoses (n= 50; 87.7%) and a history of self-harm, suicidal ideation, or symptoms of distress were also common. Global level of functioning was impaired (range 25–95/100; mean = 54.88;SD= 15.40; median = 55.00). There were no differences between children with gender dysphoria and children with mixed psychiatric disorders on attachment patterns (χ2= 2.43;p= 0.30) and rates of unresolved loss and trauma (χ2= 0.70;p= 0.40).Post hocanalyses showed that lower SES, family constellation (a non-traditional family unit), ACEs—including maltreatment (physical abuse, sexual abuse, emotional abuse, neglect, and exposure to domestic violence)—increased the likelihood of the child being classified into a high risk attachment pattern. Akin to children with other forms of psychological distress, children with gender dysphoria present in the context of multiple interacting risk factors that include at-risk attachment, unresolved loss/trauma, family conflict and loss of family cohesion, and exposure to multiple ACEs. (shrink)